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1. Design and synthesis of novel quinoxaline-polyphenol (natural) hybrid molecules.

2. Optimization of various natural polyphenols based on their anti-oxidant activity.

3. Biological evaluation of the synthesized library against pancreatic alpha amylase, alpha glucosidase and anti-oxidant activities.

4. Testing the most promising compound in the mammalian cell culture model for potential anti-diabetic property as well as cytotoxicity.

Diabetes is a major public health threat that is approaching at an epidemic proportions worldwide. It is a leading cause of mortality right after cardiovascular diseases and cancer. Diabetes renders a huge economic burden to the society because of the complications it can cause. However, there are very few oral drugs that can effectively fight against diabetes and metformin and acarbose are the two most-used drugs. However, they both have serious side effects and hence, there is a pressing need for alternatives that will effective yet safer. Herein, we propose a novel quinoxaline-polyphenol (natural) hybrid scaffold as highly effective anti-diabetic molecule. Our preliminary data with selected hybrid molecules comprised of curcumin (a natural polyphenol) and quinoxaline exhibited excellent anti-diabetic properties by effectively inhibiting two critical enzymes (pancreatic alpha amylase and alpha glucosidase) that are well -established to cause diabetes. More importantly, oxidative stress due to the exposure of reactive radicals (e.g. for smokers) adversely affects the diabetic patients. Our proposed molecule possess excellent antioxidant activities. Hence, it can further protect the pancreatic beta cells from this toxic radicals. Our preliminary experimental findings are further supported by molecular docking studies. Here, in this proposed work we would like to further optimized our designed molecule and expand the library with more active polyphenols (such as green tea polyphenols) and structurally diverse quinoxaline derivatives to synthesis a library of hybrid molecules and test their efficacy to treat diabetes (type-II). As designed molecules are made of natural products, we believe they will be safer and result in minimal to nil side effects. Here we will put more emphasis on the green tea polyphenols as they are well-documented to have anti-diabetic activities

To design molecules to be a natural alternative to the existing anti-diabetic drugs with high potency and minimum adverse side effects.

The natural polyphenols will pose minimal side effects as they are of natural origin.