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Mosquito Control through Understanding Insecticide Resistance via Structural Biology

Status: New

Lab/Organization
Name & address of the Laboratory/Organization Indian Institute of Technology (IIT), Mandi
Website address www.iitmandi.ac.in
Affiliated to which Department/Ministry Indian Institute of Technology (IIT)
CSR Registration Number CSR00057737
Registration under 12A AAALI0149JF20221
Registration under 80G Exemption under notification vide no. CCIT(E)/order u/s 80G(2)(a)(iiif)/2016-17/1480
Name of the CSR Nodal Prof. Varun Dutt
Contact information of CSR Nodal +91 1905 27945, dora@iitmandi.ac.in
Principal Investigator Dr. Baskar Bakthavachalu, baskar@iitmandi.ac.in
Baskar Lab - Research
Co- Principal Investigator (Co-PI)
Project Detail
Objective on the basis of need

To understand the molecular mechanisms behind insecticide resistance in mosquitoes and develop new insecticide strategies to improve vector control programs.
Executive summary of the proposed project (In 250 words)

This project focuses on investigating the molecular mechanisms of insecticide resistance in Aedes aegypti mosquitoes through structural biology techniques. By analyzing voltage-gated sodium channels (VGSCs) using cryo-EM imaging, we aim to uncover the structural basis of resistance to pyrethroid insecticides. The research will guide the development of novel insecticides, addressing a critical public health challenge posed by vector-borne diseases.
Technology Readiness Level (If not a new project but an advancement of existing know how) TRL 5 - Technology validated in the relevant environment.
Outomes or Deliverables

Improved crop yields and quality.

- High-resolution structures of VGSC wild-type and kdr mutant channels. 
- Structural insights into insecticide resistance mechanisms. 
- Development of new insecticides targeting resistant mosquito strains.
Project aligned with which most relevant UN SDGs Goal 3 - Good Health & Well-Being
Goal 9 - Industry, Innovation & Infrastructure
Duration (In years) 3 years
Expected Impact

- Enhanced understanding of mosquito-borne disease control. 
- Develop effective insecticides to reduce disease transmission. 
- Improved public health outcomes globally.
Implementation model (self- implemented/ outsourced partnership) Self-implemented with collaboration from structural biologists and entomologists.
Total Budget (Recurring +Non-Recurring Expenses) INR 1.13 Crores
 
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