Status: New
| Name & address of the Laboratory/Organization | Indian Institute of Technology (IIT), Palakkad | |
| Website address | https://iitpkd.ac.in/ | |
| Affiliated to which Department/Ministry | Indian Institute of Technology (IIT) | |
| CSR Registration Number | CSR00006228 | |
| Registration under 12A | ||
| Registration under 80G | ITBA/EXM/S/80G/2020-21/1027823431(1) dated 28/08/2020 | |
| Name of the CSR Nodal | Sureshkumar Chekkala | |
| Contact information of CSR Nodal | 9494143565, aricsr@iitpkd.ac.in | |
| Principal Investigator | Prof. Haridas, haridasv@iitpkd.ac.in https://iitpkd.ac.in/user/16552 |
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| Co- Principal Investigator (Co-PI) | ||
| Objective on the basis of need | "To detect and continuously monitor low amount of fluoride in drinking water. Intended to develop novel orthogonal systems that (i) bind and gives a visual change enabling us to detect and quantify the analyte (ii) All solid-state potentiometric sensor strips for periodic and continuous monitoring of fluoride ion. |
| Executive summary of the proposed project (In 250 words) | "We intend to develop a molecular sensor for toxic anions like Fluoride. This sensor not only binds to anions, but also gives an identifiable color to the naked eye. Therefore, a host system that can bind the negatively charged spherical species through several non-covalent interactions, along with the right cavity size needs to be considered for the design. Another aspect of the design is the change in the emission property of the host upon binding the guest anionic species. We intend to develop short amide-based systems for this purpose. The amide provides the hydrogen bond donor sites for interacting with anions. We have good expertise in various host systems and believe that will help in undertaking this project. To develop a molecule that bind an analyte, requires complementary sites for binding and the right geometry of the binding site. In this case, we do a molecular engineering approach for developing a fluoride sensor. The fluoride, with its high negative charge and small spherical size requires appropriate a binding site. The hydrogen bonding, anion-π interactions and electrostatic interactions are the possible modes of binding. Keeping this in mind, we intend to develop few systems that could show specific and enhanced binding to fluoride. Another challenge in the design is the binding in aqueous media. The highly negative free energy of hydration for fluoride ions necessitates searching for a sensing system with a high affinity towards fluoride recognition. Most of the molecular receptors operate in organic media but fail in aqueous solution due to its poor solubility and the strong solvating power of water towards anions. To outcompete the hydrogen bonding of water with anion, the host design must have precisely defined complimentary groups. We will address this challenge by a combined molecular engineering strategy. We will also attempt a rational design approach using computational methods. The fine tuning of the conformation and incorporation of hydrogen bond donor units and the optimization of geometry will be investigated by computational molecular dynamics." |
| Technology Readiness Level (If not a new project but an advancement of existing know how) | 5 |
| Outomes or Deliverables | Quantitative detection of fluoride |
| Project aligned with which most relevant UN SDGs | Goal 6 - Clean Water & Sanitataion Goal 11 - Sustainable Cities & Communities |
| Duration (In years) | 2 |
| Expected Impact | Rural and urban India |
| Implementation model (self- implemented/ outsourced partnership) | Self - implemented |
| Total Budget (Recurring +Non-Recurring Expenses) | 33 Lakhs |